The Hopeless

"Making the world hopeless..."- Tooltip

The Hopeless is a biome unlocked after unlocking Nightmare Mode. It has Zetsubark trees and mainly consists of Scab Blocks and Despairstone blocks. It will not spread until one has bested the Ultimate Despair, though doing this also triggers the spread of The Hope. It is a dreary and dark place, mainly consisting of red, black and white.

Blocks

 * Scab Blocks
 * Zetsubark
 * Despairstone

Enemies

 * Des-bear
 * Remnant of Despair
 * Hopeless Zombie
 * Zetsuball
 * Despairing Skeleton
 * Monocub

Loot

 * Soul of Despair (all)
 * Monoclaw (Des-bear and Monocubs)
 * Hope Fragment (Remnant of Despair)